Process for the preparation of an acetonitrile derivative

Details Process for the preparation of an acetonitrile derivative Process for the preparation of an acetonitrile derivative

1978-05-10

1979-05-22

Brust, Joseph Paul

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C12000

Patent

active

041559290

ABSTRACT:
Process for the preparation of di-n-propyl acetonitrile of the formula: ##STR1## whereby, in a single step, sodium n-propylate in n-propanol medium is added to a reaction medium which is formed of a cyanacetate of general formula: ##STR2## in which R represents an alkyl radical having from 1 to 4 carbon atoms, and n-propyl bromide or iodide, the alkylation reaction taking place under reflux, the crude ester obtained is saponified with a 10 to 20% solution of sodium hydroxide or potassium hydroxide, the resulting salt is acidified with a strong acid, to give crude di-n-propyl cyanacetic acid, which is decarboxylated by heating at a temperature between 140.degree. C. and 190.degree. C., so as to obtain the di-n-propyl acetonitrile.

REFERENCES:
marshal, J. Chem. Soc., (1930), pp. 2754-2761.
Brown, et al., J.A.C.S., (1955), pp. 1083-1089, 77.
Newman, et al., J.A.C.S., (1960), pp. 873-875, 82.
Hessler, et al., J.A.C.S., 43 (1921), pp. 205-208.
Newman, et al., J.A.C.S., 80 (1958), pp. 6350-6355.

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