Process for the preparation of 1,4-benzo-diazepines and 1,4-benz

Details Process for the preparation of 1,4-benzo-diazepines and 1,4-benz Process for the preparation of 1,4-benzo-diazepines and 1,4-benz

1976-07-23

1979-05-22

Rush, Raymond V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602393D, C07D24316, C07D24328

Patent

active

041559045

ABSTRACT:
This invention relates to an improved process for the preparation of 1,3-dihydro-2H-1,4-benzodiazepin-2-ones and 2,3-dihydro-1H-1,4-benzodiazepines by the condensation of a 2-(2-haloacylamido)-benzophenone or a 2-(2-haloethylamino)-benzophenone, respectively, in the presence of hexamethylenetetramine, a water miscible alcohol containing 5 to 50 volume percent water, and an ammonium salt.

REFERENCES:
patent: 3136815 (1964-06-01), Reeder et al.
patent: 3583978 (1971-06-01), Archer et al.
patent: 3714145 (1973-01-01), Bell et al.
patent: 3996209 (1976-12-01), Chase
Blazevic et al.--J. Het. Chem.--vol. 7 (1970)--pp. 1173-1174.
Blazevic et al.--J. Het. Chem.--vol. 9 (1972)--pp. 531-537.
Migroichian--"Organic Synthesis"--vol. I--pp. 465-469, Reinhold Publ. Corp (1957).

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