Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Patent
1984-10-04
1991-06-25
Weimar, Elizabeth C.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
435 85, 536 25, C12P 1942, C12P 1928, C07H 2300
Patent
active
050266403
ABSTRACT:
The invention relates to a process for the conversion of corrinoids produced by microorganisms into cyanocorrinoids by reaction with cyanides. According to the invention a fermentation broth obtained by disruption of microorganism cells in a known manner, preferably by heat treatment in the presence or absence of sulfite ions, optionally after purification steps known per se, is contacted with a suitable adsorbent or ion exchange resin, the corrinoids adsorbed on the surface of the adsorbent or ion exchange resin are treated with an aqueous solution containing cyanide ions or a compound capable of supplying cyanide ions, in an amount providing cyanide ions in a 1.1 to 2.0-fold molar excess related to the corrinoids, the adsorbent or ion exchange resin is washed with water, and the cyanocorrinoids obtained is eluted in a known manner, preferably with aqueous ethanol.
REFERENCES:
patent: 3037016 (1962-05-01), Barker
patent: 3115489 (1963-12-01), Cords et al.
patent: 3163637 (1964-12-01), Chaiet
patent: 3846237 (1974-11-01), Toohey
Cserey Pechany Eva
Jaksa Istvan
Kelemen Agnes
Dubno Herbert
Myers Jonathan
Poulos Gail
Richter Gedeon Vegyeszeti Gyar Rt
Weimar Elizabeth C.
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