Method and apparatus for bonding a polypeptide to a macromolecul

Chemistry: electrical and wave energy – Processes and products – Processes of treating materials by wave energy

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C08L 100

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active

050715291

ABSTRACT:
A method for immobilizing proteins and large polypeptides on a carrier support for solid-phase sequence. Upon irradiation, a functional group bound to the carrier is excited to a triplet biradical state and thereby rendered capable of bonding to amino acid units; unbound functional groups return to their starting state upon removal of the radiation.

REFERENCES:
patent: 4039413 (1977-08-01), Kraemer
patent: 4451568 (1984-05-01), Schneider
Laursen et al., "Coupling Methods and Strategies in Solid-Phase Sequencing", Molecular Biology, Biochemistry and Biophysics, vol. 25, (1977), pp. 21 and 29-31.

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