Phenylthioaralkylamines

Details Phenylthioaralkylamines Phenylthioaralkylamines

1974-11-25

1977-04-19

Hines, Robert V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260243B, 2602471R, 260268R, 260268C, 26029373, 26050121, 260516, 260544N, 260558S, 260562P, 424246, 424248, 424250, 424267, 424316, 424330, 42424852, C07C 9728

Patent

active

040188302

ABSTRACT:
Phenylthioaralkylamines and 2-phenylthiobenzylamines are prepared by reaction of the corresponding phenylthiobenzoyl chloride or homologs thereof with ammonia or an amine to produce the corresponding phenylthiobenzamide or N-substituted or N,N-disubstituted derivative thereof followed by reduction with lithium aluminum hydride to produce the corresponding phenylthiobenzylamine or the N-substituted or N,N-disubstituted derivative thereof. The compounds are also prepared by reaction of the corresponding phenylthiobenzyl halide with ammonia or a selected amine. The compounds are active as antiarrhythmics.

REFERENCES:
patent: 3812177 (1974-05-01), Engelhardt et al.
Knabe et al., "Archiv der Pharmazie", vol. 295, No. 9, pp. 690-697, (1962).
Its, "Chemical Abstracts", vol. 52, pp. 9005-9006, (1958).

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