Novel 2-substituted alkyl carbapenem antibacterials

Details Novel 2-substituted alkyl carbapenem antibacterials Novel 2-substituted alkyl carbapenem antibacterials

1990-06-21

1991-06-04

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D48704

Patent

active

050215655

ABSTRACT:
Described is a new process for producing new 2-substituted alkyl-3-carboxycarbapenems, involving condensation of a 2-oxocarbapenam-3-carboxylic ester with a stabilized ylide followed by ester deblocking. The resulting carbapenem compounds, which are not readily available from other known synthetic routes, show interesting antibacterial activity.

REFERENCES:
Chem. Abs. vol. 101, No. 25 (1984) p. 743.
J. Org. Chem., vol. 49 (1984), pp. 5271-5272.
Tetrahdron Letters, vol. 25, No. 52 (1984) pp. 5989-5992.
J. Chem. Soc. Chem. Comm., No. 22 (1984), pp. 1513-1514.

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