Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-06-06
1997-10-28
Henley, III, Raymond
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
546300, 546334, 546336, 560142, 564157, 564219, 564248, C07D20746, C07D21172, C07D21170, C07C 6900, C07C23300, C07C24900
Patent
active
056819650
ABSTRACT:
Compositions containing as the active ingredient a spin-trapping reagent, preferably .alpha.-phenyl butyl nitrone (PBN) or spin-trapping derivatives thereof, in a suitable pharmaceutical carrier for administration to a patient are disclosed for treating or preventing symptoms associated with aging or other conditions associated with oxidative tissue damage. Other spin-trapping agents can also be used, such as 5,5-dimethyl pyrroline N-oxide (DMPO) or .alpha.-(4-pyridyl 1-oxide)-N-tert-butylnitrone (POBN), and other spin-trapping derivatives thereof. These compositions and methods are useful in the treatment of age-related disorders, pre-surgical and/or pre-anesthetic preparation or administration of chemotherapeutic agents, and in the treatment of disorders or trauma of the brain, cardiovascular system, and lymphatic system. Studies in animals demonstrate that administration of compound for a two week period reduces the level of oxidized brain enzymes to normal and restores memory to the same level as tested in young control animals.
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W.B. Weglickl et al., "Applications of Spin Trapping Techniques in Models of Cardiovascular Injury" in Oxy-Radicals in Molecular Biology and Pathology, pp. 357-364 1988.
Hinton et al., "Synthesis of Characterization of Phenyl-Substituted C-Phenyl-N-tert-butylnitrones and Some of Their Radical Adducts", J. Org. Chem., 1992, 57, pp. 2646-2651.
Carney John M.
Floyd Robert A.
Henley III Raymond
Oklahoma Medical Research Foundation
University of Kentucky Research Foundation
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