Certain pyridyl-thiazolidin-4-one having anti-ulcer activity

Details Certain pyridyl-thiazolidin-4-one having anti-ulcer activity Certain pyridyl-thiazolidin-4-one having anti-ulcer activity

1989-01-17

1991-06-04

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546280, C07D41704, A61K 3144

Patent

active

050214357

ABSTRACT:
A 2-pyridyl-thiazolidin-4-one derivative represented by the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each a hydrogen atom, an C.sub.1 -C.sub.20 alkyl group, an C.sub.2 -C.sub.20 alkenyl group, an C.sub.2 -C.sub.20 alkynyl group, an aryl group, a C.sub.3 -C.sub.8 cycloalkyl group or an aralkyl group which may have a substituent, R.sub.3 is a hydrogen atom, an C.sub.1 -C.sub.20 alkyl group, an C.sub.2 -C.sub.20 alkenyl group, an C.sub.2 -C.sub.20 alkynyl group, a C.sub.3 -C.sub.8 cycloalkyl group or an aralkyl group which may have a substituent, P is a pyridyl group or its N-substituted pyridinium salt which may have a substituent, said substituent being selected from the group consisting of halogen atom, cyano group, hydroxy group, amino group, lower alkyl group, lower alkoxy group, lower alkylamino group, halogenated lower alkyl group, acyl group, acyloxy group, acylthio group, acylamino group, carboxyl group, lower alkoxycarbonyl group, carbamoyl group, lower alkyl substituted carbamoyl group, heterocyclic group, and lower cycloalkyl group, and n represents an integer of 0, 1 or 2, or a pharmaceutically acceptable salts thereof and an anti-ulcer agent which contains, as an effective ingredient, said 2-pyridyl-thiazolidine-4-one derivative or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 2910479 (1959-10-01), deStevens
patent: 3705153 (1972-12-01), Kaneko et al.
patent: 4017628 (1977-04-01), Nitidandhaprabhas
patent: 4406905 (1983-09-01), Zahner et al.
patent: 4434172 (1984-02-01), Kawasaki et al.
patent: 4501746 (1985-02-01), Krumkalns
patent: 4849434 (1989-07-01), Enomoto et al.
Chem. Abstracts, vol. 109(1), Abst. No. 6503q, Jul. 4, 1988.
Chem. Abstracts, vol. 107(7), Abst. No. 54190h, Aug. 17, 1987.
Chem. Abstracts, vol. 93(25), Abst. No. 239,437e, Dec. 22, 1980.
Chem. Abstracts, vol. 92(13), Abst. No. 110,995k, Mar. 31, 1980.
J.A.C.S., 75, 109-114 (1953), Pennington et al.
J.A.C.S., 76, 578-580 (1954), Surrey et al.
J.A.C.S., 70, 3436-3439 (1948), Troutman et al.
J. Indian Chem. Soc., vol. LIV, 1977, 765-768, Vakil.
J. Indian Chem. Soc., vol. LIII, 1976, 595-597, Singh.
J. Indian Chem. Soc., vol. LV, 1978, 424-426, Jadhav et al.
J. Biol. Chem., 255, 5514-5516 (1980), Hanahan et al.

Affiliated with

Also associated with

Rating

Certain pyridyl-thiazolidin-4-one having anti-ulcer activity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Certain pyridyl-thiazolidin-4-one having anti-ulcer activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Certain pyridyl-thiazolidin-4-one having anti-ulcer activity will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1026615