Fluorescent 1-peptidylaminoalkanephosphonate derivatives

Details Fluorescent 1-peptidylaminoalkanephosphonate derivatives Fluorescent 1-peptidylaminoalkanephosphonate derivatives

1994-10-18

1997-10-28

Hill, Jr., Robert J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 18, 514 7, 530331, 435 4, A61K 3805

Patent

active

056818211

ABSTRACT:
Fluorescent 1-peptidylaminoalkanephosphonate derivatives, and their use in detecting and studying the distribution of serine proteases in cells and biological systems.

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patent: 5164300 (1992-11-01), Marshall
Meldal Analy & Chem 195, 141, 1991.
Oleksyszen Biochem Biophys Res Comm 161, 143, 1989.
Synthesis of New Phosphonate Inhibitors of Serine Proteases, Fastrez, Jespers, Lison, Renard, and Sonveaux, Tetrahedron Letters, vol. 30, No. 49, pp. 6861-6864, 1989.
Synthesis of Phosphonopeptides as Thrombin Inhibitors, Wang, Taylor, Mical, Spitz, and Reilly, Tetrahedron Letters, vol. 33, No. 50, pp. 7667-7670, 1992.
Inhibition of Chymotrypsin by Phosphonate and Phosphonamidate Peptide Analogs, Bartlett and Lamden, Bioorganic Chemistry 14, 356-377 (1986).
Irreversible Inhibition of Serine Proteases by Peptide Derivatives of (.alpha.-Aminoalkyl) Phosphonate Diphenyl Esters, Oleksyszyn and Powers, Biochemistry, 1991, 30.
Novel Amidine-Containing Peptidyl Phosphonates as Irreversible Inhibitors for Blood Coagulation and Related Serine Proteases, Oleksyszyn, Boduszek, Kam, and Powers, Journal of Medicinal Chemistry, 1994.
Aminoalkylphosphonofluoridate Derivatives: Rapid and Potentially Selective Inactivators of Serine Peptidases, Lamden and Bartlett (1983).

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