Thiopropionamides, and the pharmaceutical compositions

Details Thiopropionamides, and the pharmaceutical compositions Thiopropionamides, and the pharmaceutical compositions

1978-09-25

1981-08-11

Ford, John M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

548200, 544 54, 544 582, 544 584, C07D27706, A61K 31425

Patent

active

042834074

ABSTRACT:
This invention relates to omega-mercaptopropionylamides, the nitrogen atom of which is included as a ring atom of a cyclic amino acid.
The application also discloses a process for producing said compounds which comprises reacting an omega-mercaptopropionic acid, or a functional derivative thereof, with a cyclic amino acid.
This invention further relates to pharmaceutical compositions incorporating such an omega-mercaptopropionylamide as active ingredient together with a pharmaceutically-acceptable carrier or vehicle, and a method of employing said compounds.
They find a use in human therapy, namely, as antihypertensive agents.

REFERENCES:
patent: 4192878 (1980-03-01), Ondetti
Mita et al., Chem. Pharm. Bull, vol. 26, pp. 1333-1335 (1978).

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