7-N-Heterocyclyl cephalosporins and antibiotic pharmaceutical co

Details 7-N-Heterocyclyl cephalosporins and antibiotic pharmaceutical co 7-N-Heterocyclyl cephalosporins and antibiotic pharmaceutical co

1979-08-01

1981-08-11

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544 21, 544 22, 544 25, 544 27, 544 28, 546 13, 546346, 546343, 546341, 546283, A61K 31545, C07D50114

Patent

active

042833973

ABSTRACT:
Disclosed are antibiotic cephalosporins (I) of the formula: ##STR1## wherein the stylized radical attached to the 7-amino nitrogen of the cephalosporin moiety represents a nitrogen-containing heterocyclic group (mono- or polycyclic); R is, inter alia, hydrogen, alkyl, heterocyclylalkyl, aryl, alkenyl, aralkyl, --NR.sub.2, --OR, COOR, CONR.sub.2 or CN; A is H or is conventionally known in the cephalosporin art; R.sup.2 is H, or loweralkoxyl; p is 1 or 2; and R.degree. is H or CH.sub.3. Also disclosed are the pharmaceutically acceptable salt and ester derivatives of I; processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.

REFERENCES:
patent: 3646024 (1972-02-01), Holdrege et al.
patent: 3821198 (1974-06-01), Lee et al.
patent: 3929779 (1975-12-01), Bickel et al.
patent: 3957764 (1976-05-01), Lund
patent: 4042585 (1977-08-01), Koppel
patent: 4092474 (1978-05-01), Yoshioka et al.
patent: 4168309 (1979-09-01), Ayres

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