Steroidal [16.alpha.,17-d]isoxazolidines

Details Steroidal [16.alpha.,17-d]isoxazolidines Steroidal [16.alpha.,17-d]isoxazolidines

1976-02-13

1977-04-19

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26039745, C07J 1700

Patent

active

040187748

ABSTRACT:
Novel steroids having the structure ##STR1## and the 1,2-dehydro derivatives thereof, wherein R.sub.1 is hydrogen, hydroxy, alkanoyloxy, fluorine, chlorine, or bromine; R.sub.2 is alkyl or aryl; R.sub.3 is alkyl, aryl, alkanoyl, aroyl, alkoxycarbonyl, or cyano; R.sub.4 is hydrogen, alkyl, or aryl; R.sub.5 is hydrogen, fluorine or methyl; R.sub.6 is carbonyl, .beta.-hydroxymethylene, or .beta.-chloromethylene; R.sub.7 is hydrogen or methyl; and R.sub.8 is fluorine or chlorine; have useful anti-inflammatory activity.

REFERENCES:
patent: 3340255 (1967-09-01), Wagner-Jauregg
patent: 3349084 (1967-10-01), Ayers et al.

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