Process for the separation of L-leucine and L-isoleucine

Details Process for the separation of L-leucine and L-isoleucine Process for the separation of L-leucine and L-isoleucine

1984-05-22

1985-12-31

Shapiro, Lionel M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

435280, C12P 1306, C07P 4100

Patent

active

045621535

ABSTRACT:
The separation of L-leucine and L-isoleucine in aminoacid mixtures containing at least 30 weight percent L-leucine, at most 70 weight percent L-isoleucine and at most 40 weight percent of other aminoacids is accomplished by acetylating the mixture, precipitating the acetylation product by acidification, subjecting the aqueous solution to a saponification by an L-aminoacid acylase until 25 to 95% of the N-acetyl-L-leucine is saponified, crystallizing pure L-leucine from the saponification mixture and separating it off, isolating N-acetyl-L-isoleucine from the mother liquor and saponifying it in known manner to the free aminoacid and isolating the free aminoacid.

REFERENCES:
patent: 3841966 (1974-10-01), Soichiro et al.
patent: 4259441 (1981-03-01), Bauer

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