Method for reducing intraocular pressure in warm-blooded animals

Details Method for reducing intraocular pressure in warm-blooded animals Method for reducing intraocular pressure in warm-blooded animals

1977-01-17

1978-06-13

Meyers, Albert T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

424311, 424312, A61K 31455, A01N 924

Patent

active

040949834

ABSTRACT:
Intraocular pressure in warm-blooded animals is reduced by topically applying to the eye thereof, an effective ophthalmologically acceptable amount of a compound of the formula: ##STR1## wherein R represents a member selected from the group consisting of hydrogen or a C.sub.1 -C.sub.5 straight or branched alkyl group; and wherein R.sub.1 and R.sub.2, which may be the same or different, represents an acyl member selected from the group consisting of alkanoyl having 1-22 carbon atoms, alkenoyl having one or two double bonds and having 4-22 carbon atoms, ##STR2## having a total of 4-10 carbon atoms of which 3-7 are ring carbon atoms in cycloalkyl and wherein n is zero, one, or two, phenoxyacetyl, naphthalenecarbonyl, pyridinecarbonyl, ##STR3## wherein n is zero, one or two and phenyl is unsubstituted or is substituted by 1-3 alkyl having 1-4 carbon atoms, alkoxy having 1-4 carbon atoms, halo, trifluoromethyl, dialkylamino having 2-8 carbon atoms, and alkanoylamino having 1-6 carbon atoms; or an ophthalmologically acceptable acid addition salt thereof.

REFERENCES:
patent: 3657244 (1972-04-01), Mentrup et al.
patent: 3809714 (1974-05-01), Hussain et al.
patent: 3839584 (1974-10-01), Hussain et al.
patent: 3922348 (1975-11-01), Seidehamel et al.
patent: 3937838 (1976-02-01), Wetterlin et al.
patent: 3959485 (1976-05-01), Windheuser
patent: 4031242 (1977-06-01), Jones et al.

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