Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-06-13
1993-01-19
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549332, A61K 31335, C07D40710
Patent
active
051807386
ABSTRACT:
The present invention is related to a compound of the formula ##STR1## wherein R.sup.1 is a 2-methyl-1-propenyl or isobutyl group which may be substituted and R.sup.2 is (1) a substituted alkanoyl group, (2) a substituted aroyl group having at least one substituent selected from the group consisting of C.sub.2-6 alkyl, amino, halogen, hydroxyl, lower alkoxy, cyano, carbamoyl and carboxyl, (3) an aromatic heterocycle-carbonyl, which may optionally be substituted, (4) a carbamoyl group, which may optionally be substituted, (5) an alkyl group, which may optionally be substituted, (6) a benzenesulfonyl group, which may optionally be substituted, (7) an alkylsulfonyl group, which may optionally be substituted, (8) a sulfamoyl group, which may optionally be substituted, (9) an alkoxycarbonyl group, which may optionally be substituted or (10) a phenoxycarbonyl group, which may optionally be substituted; or a salt thereof.
The compound (I) has a strong angiogenesis inhibitory activity.
REFERENCES:
patent: 4954496 (1990-09-01), Oku
Goto, et al., Chemical Abstracts, 106:706 (1987), Abstract No. 176153y.
Corey, et al., Journal of the American Chemical Society, 94(7):2549-2550 (1972).
Landquist, Journal of the Chemical Society, 1956, pp. 4237-4245.
Maevskii, et al. Chemical Abstracts, 70:206 (1969), Abstract No. 36365g.
Taylor, S. et al., Nature, 297, 307 (1982).
Folkman, J. et al., Science, 221, 719 (1983).
Tarbell, D. S. et al., J. Am. Chem. Soc., 83, 3096 (1961).
Mitunobu, O., Synthesis, 1981, 1.
Sutherland, I. O. (ed.), "Comprehensive Organic Chemistry", vol. 2, pp. 4-11, Pergamon Press (1979).
Gimbrone et al. J. National Cancer Institute, 52, 413-419, Feb. 1974.
Ross, J. et al., J. Am. Chem. Sox., 78, 4675 (1956).
Chemical Patent Index, Basic Abstracts Journal Section B, Week 8706, Abstract No. 87-040948/06, Abstract of JP-A-476/1987, 1987.
J. A. DiPaolo et al. Antibiotics Annual, 1958-1959, pp. 541-546.
Chemical Abstracts 106(23): 194770b, Jun. 8, 1987.
Fujita Takeshi
Kishimoto Shoji
Conlin David G.
Haley Jacqueline
Lee Mary C.
Resnick David S.
Takeda Chemical Industries
LandOfFree
Fumagillol derivatives and pharmaceutical compositions thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Fumagillol derivatives and pharmaceutical compositions thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fumagillol derivatives and pharmaceutical compositions thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-102367