Pharmaceutical compositions containing 5-phenyl-1,3-dioxoalkenyl

Details Pharmaceutical compositions containing 5-phenyl-1,3-dioxoalkenyl Pharmaceutical compositions containing 5-phenyl-1,3-dioxoalkenyl

1986-03-28

1987-03-10

Reamer, James H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514540, 514541, 514676, 514621, 514678, 514679, 514682, 568306, 568308, 568325, 560 21, 560 23, 560 51, 560 53, 564166, 564169, A61K 31235

Patent

active

046491570

ABSTRACT:
This invention relates to pharmaceutical compositions containing a class of 5-phenyl-1,3-dioxoalkenyl compounds useful as inhibitors of leukotriene biosynthesis and thus useful in the treatment of conditions associated with leukotrienes. This invention also relates to the use of the 5-phenyl-1,3-dioxoalkenyl compounds in the inhibition of leukotriene biosynthesis and thus in the treatment of conditions associated with leukotrienes. This invention further relates to a novel process for the preparation of the 5-phenyl-1,3-dioxoalkenyl compounds.

REFERENCES:
patent: 4130661 (1978-12-01), Kulsa et al.
patent: 4228105 (1980-10-01), Jeck
patent: 4483868 (1984-11-01), Christidis et al.
patent: 4567279 (1986-01-01), Chan
patent: 4587260 (1986-05-01), Smerbeck et al.
M. Griffin et al., "Effects of Leukotriene D on the Airways in Asthma," N. Engl. J. Med, 308, 436-439 (1983).
J. D. Levine et al., "Role of Polymorphonuclear Leukocyte in Hyperalgesia," J. Neuroscience, 5, 3025-3029 (1985).
R. A. Lewis & K. F. Austen, "Mediation of Local Homeostasis and Inflammation by Leukotrienes . . . ," Nature, 293, 103-108 (1981).
F. Michelassi et al., "Leukotriene D.sub.4 : A Potent Coronary Artery Vasoconstrictor Associated with Impaired Ventricular Contraction," Science, 217, 841-843 (1982).
J. A. Burke et al., "Leukotrienes C.sub.4, D.sub.4, and E.sub.4 : Effects on Human and Guinea-Pig Cardiac Preparations in Vitro," J. Pharmacol. and Exp. Therap., 221, 235-241 (1982).
P. Sirois, "Pharmacology of the Leukotrienes," in Advances in Lipid Research, 21, 79-101 (1985).
M. K. Bach, "Inhibitors of Leukotriene Synthesis and Action" in The Leukotrienes: Chemistry and Biology, L. W. Chakrin & D. M. Bailey, eds., pp. 163-194 (Orlando: Academic Press, 1984).
M. K. Bach, "Commentary. Prospects for the Inhibition of Leukotriene Synthesis," Bioch. Pharmacol., 33, 515-521 (1984).
C. W. Lee et al., "Human Biology and Immunoreactivity of Leukotrienes" in Advances in Inflammation Research, 6, 219-225 (1984).
P. Sharon & W. F. Stenson, "Enhanced Synthesis of Leukotriene B.sub.4 by Colonic Mucosa in Inflammatory Bowel Disease," Gastroenterology, 84, 454-460 (1984).
E. L. Becker, "Chemotactic Factors of Inflammation," Trends Pharmacol. Sci., 4, 223-225 (1983).
Editorial, "Leukotrienes and Other Lipoxygenase Products in the Pathenogenis and Therapy of Psoriasis and Dermatoses," in Arch. Dermatol., 119, 541-547 (1983).
B. Samuelsson, "Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflammation," Science, 220, 568-575 (1983).
R. A. Lewis et al., "Review of Recent Contributions on Biologically Active Products of Arachidonate Conversion," Int. J. Immunopharmac., 4, 85-90 (1982).
M. W. Musch et al., "Stimulation of Colonic Secretion by Lipoxygenase Metabolites of Arachidonic Acid," Science, 217, 1255-1256 (1982).
J. March, Advanced Organic Chemistry, 2nd edition, pp. 854-859 (New York: McGraw Hill Book Company, 1977).
S. N. Hucklin & L. Weiler, "Aldol Reactions of the Dianion of .beta.-Keto Esters," Tetrahedron Lett., 4835-4838 (1971).
T.-H. Chan & P. Brownbridge, "Reaction of Electrophiles with 1,3-Bis(trimethyl siloxy)-1-methoxybuta-1,3-diene . . . ," J.C.S. Chem. Comm., 578-579 (1979).
T.-H. Chan & P. Brownbridge, "Biomimetic Synthesis of Sclerin," J.C.S. Chem. Comm., 20-21 (1981).
W. Lehnert, "Knoevenagel Condensations with TiCl.sub.4 /Base-V.," Synthesis, 667-669 (1974).
W. Lehnert, "Knoevenagel Condensations with TiCl.sub.4 /Base-II.,"Tetrahedron, 28, 663-666 (1972).
B. Weidman & D. Seebach, "Organometallic Compounds of Titanium and Zirconium as Selective Nucleophilic Reagents . . . ," Angew. Chem. Int. Ed. Engl., 22, 31-45 (1983).
M. T. Reetz, "Organotitanium Reagents in Organic Synthesis. A Simple Means to Adjust Reactivity and Selectivity of Carbanions," in Top. Curr. Chem., 106, 1-54 (1982).
T. Mukaiyama, "Titanium Tetrachloride in Organic Synthesis," Angew. Chem. Int. Ed. Engl., 16, 817-826 (1977).
R. Tabacchi, L. Vuitel, & A. Jacot-Guillarmod, "Etudes Sur Les Composes Organometallique, IX." Helv. Chim. Acta, 53, 1495-1499 (1970).
B. A. Jakschik, S. Falkenheim, & C. W. Parker, "Precursor Role of Arachidonic Acid in Release of Slow Reacting Substance . . . ," Proc. Natl. Acad. Sci. U.S.A., 74, 4577-4581 (1977).

Affiliated with

Also associated with

Rating

Pharmaceutical compositions containing 5-phenyl-1,3-dioxoalkenyl does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pharmaceutical compositions containing 5-phenyl-1,3-dioxoalkenyl, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pharmaceutical compositions containing 5-phenyl-1,3-dioxoalkenyl will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1022060