Hirudin derivative

Details Hirudin derivative Hirudin derivative

1989-01-10

1993-01-19

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

530324, 530855, 514 12, 435 691, 435 696, 4353201, 536 235, A61K 3764, C07K 1300, C07H 2104, G12N 1564

Patent

active

051806681

ABSTRACT:
A hirudin derivative which has the N-terminal amino acid sequence Leu-Thr-Tyr-Thr-Asp shows high biological activity. Moreover, this hirudin derivative can be obtained very efficiently by genetic engineering preparation in yeasts.

REFERENCES:
patent: 4767742 (1988-08-01), Dodt et al.
Harvey et al, (1986) Proc. Natl. Acad. Sci. 83, 1084-1088.
Creighton, T. E. (1984) "Proteins: Structure and Molecular Properties," W. H. Freeman and Co., New York, pp. 1-24.

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