Process for the preparation of HMG-CoA reductase inhibitors and

Details Process for the preparation of HMG-CoA reductase inhibitors and Process for the preparation of HMG-CoA reductase inhibitors and

1984-11-19

1986-09-09

Milestone, Norma S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549561, C07D30930

Patent

active

046110682

ABSTRACT:
This invention relates to a novel process for the preparation of 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA) reductase inhibitors which contain a 4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one moiety, such as compactin and mevinolin, by utilizing an alkyl 5(S),6-epoxy-3(R)-(alkoxy)hexanoate as a chiral synthon for the stereospecific introduction of the 4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one moiety.

REFERENCES:
patent: 4375475 (1983-03-01), Willard et al.
patent: 4448979 (1984-05-01), Terahara et al.
I. T. Harrison et al., Compendium of Organic Synthetic Methods (1971), pp. 81 and 138.
Herr et al., Jour. Am. Chem. Soc., vol. 92:12, Jun. 17, 1970, pp. 3813-3814.
Herr et al., Jour. Am. Chem. Soc., vol. 92:16, Aug. 12, 1970, pp. 4979-4981.
C. Huynh et al., Tetrahedron Letters, No. 17 (1979) pp. 1503-1506.
M. S. Kharasch et al., Grignard Reactions of Nonmetallic Substances, (1954), pp. 961-963.
N. G. Gaylord et al., Chem. Rev., vol. 49 (1951), pp. 413-415; 424-431.
B. M. Trost et al., Tetrahedron Letters, No. 39 (1976) pp. 3477-3478.
Paul C. Anderson et al., Tetrahedron Letters, vol. 24 (13) (1983) pp. 1373-1376.
Raymond L. Funk et al., Tetrahedron Letters, vol. (16) (1984) pp. 1655,1658.

Affiliated with

Also associated with

Rating

Process for the preparation of HMG-CoA reductase inhibitors and does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of HMG-CoA reductase inhibitors and , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of HMG-CoA reductase inhibitors and will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1016095