Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Patent
1990-04-25
1991-11-12
Shah, Mukund J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
544332, C07D40304
Patent
active
050649639
ABSTRACT:
The invention provides a novel process for producing N-[3-(1H-imidazol-1-yl)phenyl]-4-(substituted)-2 pyrimidinamine compounds in which the substituent is a 2-pyridinyl, 3-pyrindinyl, 4-pyridinyl, 2-furanyl or 2-thienyl group. The process includes the steps of (1) reacting a 3-(1H-imidazol-1-yl)benzamine with cyanamide and a halogen acid while controlling the pH of the reaction between pH about 2 to abourt 3.5 and recovering a [3-(1H-imidazol-1-yl)phenyl] guanidine dihydrohalide and (2) reacting the [3-(1H-imidazol-1-yl)phenyl] guanidine dihydrohalide so recovered with an appropriately substituted 3-dimethylamino-1-(substituted)-2-propen-1-one and a base at a pH of from about 10.5 to about 11.5 and recovering the N-[3-(1H-imidazol-1-yl)phenyl-4-(substituted)-2-pyrimidamine compound so produced. The novel process provides improved yield and purity by adhering to the stated crucial pH ranges.
REFERENCES:
patent: 4788195 (1986-11-01), Torley
J. Medicinal Chemistry, 1975, vol. 18, No. 11, pp. 1077-1088.
Synthesis, Sep. 1986, pp. 777-779.
American Cyanamid Company
Grumbling Matthew V.
Shah Mukund J.
Szatkowski Thomas S.
LandOfFree
Process for the synthesis of N-(3-(1H-imidazol-1-yl)phenyl-4-(su does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for the synthesis of N-(3-(1H-imidazol-1-yl)phenyl-4-(su, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the synthesis of N-(3-(1H-imidazol-1-yl)phenyl-4-(su will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1014133