Process for preparing an optically active cyclobutane nucleoside

Details Process for preparing an optically active cyclobutane nucleoside Process for preparing an optically active cyclobutane nucleoside

1989-12-18

1991-11-12

Rivers, Diana G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen bonded directly to ring carbon of the purine ring...

556436, 560 39, 560 40, 560173, 564152, 564158, C07D47318

Patent

active

050649612

ABSTRACT:
A process for the preparation of the optically active compound [IR-(1.alpha., 2.beta., 3.alpha.)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclobutyl]-6H-purin-6-one, represented by the formula: ##STR1## and novel intermediates are described.

REFERENCES:
patent: 4855466 (1989-08-01), Zahler et al.
patent: 4918075 (1990-04-01), Zahler et al.
Ishikawa et al., "Enantio and Diastereo--selective Synthesis . . . ", J. Chem Soc., Chem Commun, 1989, pp. 1919-1921.
Norbeck et al., "Cyclobut A and Cyclobut G . . . ", J. Med. Chem., vol. 33, pp. 1281-1285 (1990).
W. Slusarchyk, et al. SQ 33,054: A Potent Member of a New Class of Nucleoside--Analog Antivirals--Abstract No. 1330--XXIX Interscience on Antimicrobial Agents & Chemo., 9/17-20/89, Houston, TX.
W. Slusarchyk, et al. Synthesis of SQ 33,054, A Novel Cyclobutane Nucleoside with Potent Antiviral Activity; Tetrahedron Letters, vol. 30, p. 6453 (1989).
M. Honjo, et al., Synthesis of the Carbocyclic Analogue of Oxetanocin A.sup.1, Chem. Pharm. Bull. 37(5) 14-13-1415 (1989).
Y. Hayashi, et al.; Asymmetric [2+2] Cycloaddition Reaction Catalyzed by a Chiral Titanium Reagent, Chemistry Letters, p. 793-796 (1989).

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