Selective adenosine reseptor compounds

Details Selective adenosine reseptor compounds Selective adenosine reseptor compounds

1990-06-27

1991-11-12

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

544251, C07H 1906, C07D48702, A61K 31735

Patent

active

050649477

ABSTRACT:
Adenosine analogues which act selectively at adenosine receptors and which act in general as adenosine antagonists are disclosed. From in vitro studies it is known that specific physiological effects can be distinguished as a result of this selectivity and that adenosine receptor activity in vitro correlates with adenosine receptor activity in vivo. Pharmaceutical preparations of the subject compounds can be prepared on the basis of the selective binding activity of the compounds disclosed herein which can be expected to enhance certain physiological effects while minimizing others, such as decreasing blood pressure without decreasing heart rate.

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Spremulli et al., "Hemodynamic . . . , " CA 98: 172756 (1983).
Derwent Abstract 74-60887V.
Derwent Abstract 76-05684X.
Derwent Aabstract 74-32976V.
T. P. Johnston et al., J. Org. Chem., 27, 974 (1962).

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