Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-09-14
1991-11-12
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514410, 548421, 544295, A61K 31495, A61K 3140, C07D40300, C07D48700
Patent
active
050648314
ABSTRACT:
Naphthothiophenimines of formula I ##STR1## wherein R.sup.1 is, inter alia, alkyl, cycloaklyl, alkenyl, phenalkyl or aminoalkyl.
Formula I compounds are useful in treating brain ischemia and resulting disorders.
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Foster, et al., Taking apart NMDA receptors, Nature, 329, p. 395 (1987).
Kemp, et al., Non-competitive antagonists of excitatory amino acid receptors, Trends in Neurosciences, 10, p. 294 (1987).
Schwarcz, et al., Excitatory Aminoacid Antagonists Provide a Therapeutic Approach to Neurological Disorders, The Lancet, vol. II, p. 140 (1985).
Robinson, et al., A Novel Rearrangement Forming 4,5,6,11-Tetrahydrobenzo[6,7]Cycloocta[1,2-b]thiophen-6,11-imines, Tetrahedron Letters, 30, p. 5203 (1989).
Bristol-Myers Squibb Co.
Grumbling Matthew V.
Han William T.
Shah Mukund J.
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