Use of branched chain amino acids to effect diaphragm contractil

Details Use of branched chain amino acids to effect diaphragm contractil Use of branched chain amino acids to effect diaphragm contractil

1990-09-14

1991-11-12

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514557, 514561, A61K 3119, A61K 31195, A61K 3700

Patent

active

050648101

ABSTRACT:
A method for reducing respiratory muscle fatigue comprising the steps of administering a composition that includes branched chain amino acids. The composition can be administered either enterally or parenterally.

REFERENCES:
patent: 4687782 (1987-08-01), Brantman
Chemical Abstracts, 107(7):56571g (1987), Mohan et al., Fatigue Induced Alterations in Muscle Transamination Patterns of Albino Rat.
BIOSIS No. 83027653, (Abstract), 1986, Fielding et al., The Effects of High Intensity Exercise on Muscle and Plasma Levels of Alpha Ketoisocaproic-Acid.
B. Skeie et al., Branch-Chain Amino Acids: Their Metabolism and Clinical Utility, Critical Care Medicine, vol. 18, No. 5, May 1990, pp. 549-571.
A. Wagenmakers et al., The Metabolic Fate of Branched-Chain Amino Acids and 2-Oxo Acids in Rat Muscle Homogenates and Diaphragms, Int. J. Biochem., vol. 17, No. 9, 1985, pp. 957-965.
T. Normal Palmer et al., Modulation of Branched-Chain Amino Acid Oxidation in Rat Hemidiaphragms in Vitro by Glucose and Ketone Bodies, Biochemistry International, vol. 11, No. 3, Sep. 1985, pp. 407-413.
S. Weinberger, M.D. et al., Hypercapnia, The New England Journal of Medicine, vol. 321, No. 18, Nov. 2, 1989, pp. 1223-1231.

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