Substituted benzamide radiosensitizers

Details Substituted benzamide radiosensitizers Substituted benzamide radiosensitizers

1990-09-24

1991-08-20

Nutter, Nathan M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564152, 564158, 564165, 564170, 564175, 564176, 564244, 564247, 568 20, 568 77, C07C32700, C07C23300, A01N 4102

Patent

active

050416537

ABSTRACT:
A method for sensitizing hypoxic tumor cells to radiation using derivatives of benzamide are disclosed. Some of the compounds useful in the method of the invention are novel.

REFERENCES:
patent: 3983164 (1976-09-01), Thorne et al.
Thraves et al., "Radiosensitization of Human Fibroblasts by 3-Aminobenzamide: An Inhibitor of Poly(ADP-Ribosylation", Radiation Research 104, 119-127 (1985).
Miyakoshi et al., "Effects of m-Aminobenzamidine on the Response of Chinese Hamster Cells to Hyperthermia and/or Radiation", Radiation Research 102, 359-366 (1985).
Coates et al., "Preparation and Evaluation of Some Phenolic Ethers as Antifungal Agents", CA 54, No. 13054e.

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