Pharmaceutical preparations

Details Pharmaceutical preparations Pharmaceutical preparations

1989-04-27

1991-09-03

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 90, 514 14, 514 15, 514 18, C07K 728, C07K 764, C07K 766

Patent

active

050455303

ABSTRACT:
A pharmaceutical preparation is disclosed which is made up of a micelle or a vesicle each consisting of a cationic tenside with a monovalent ion and a hydrophobic cyclic or linear peptide, dispersed in a solvent whose pH value lies between pH 7-pH 8, the critical micellization concentration (cmc) lying in the range of 1.0.10.sup.-7 to 7.0.10.sup.-5 mol/liter. The preparations disclosed have in particular the advantage that by the increasing of the hydrophobicity of the alkyl or aryl chain or the radical at the N.sup.+ tenside both the membrane permeability is increased and furthermore the pharmaceutical active substance, in particular linear and cyclic tyrocidines (A-J), can be transferred actively into the cytosol. They thus act on the transciption level. In addition, linear and cyclic tyrocidines in particular have antiviral effects.

REFERENCES:
patent: 4870174 (1989-09-01), Paradies
patent: 4874850 (1989-10-01), Paradies
Havel et al, Chemical Abstracts, 1983, vol. 99, 59684y.
Lundahl et al, Biochimica et Biophysica Acta, 873, (1986), pp. 20-26.

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