Tonometric fluid for blood gas and co-oximetry instruments

Details Tonometric fluid for blood gas and co-oximetry instruments Tonometric fluid for blood gas and co-oximetry instruments

1989-03-27

1991-09-03

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

436 11, 436 15, G01N 3372, G01N 3396

Patent

active

050455290

ABSTRACT:
A stable reference solution for calibrating and monitoring blood gas instrumentation is disclosed. The solution comprises an aqueous mixture containing a hemoglobin solution derived from a mammalian source which comprises at least about 95% reduced hemoglobin. The solution additionally contains a bicarbonate buffer and a metal catalyzed methemoglobin reducing system and an organic buffer. To provide a control element having a variety of properties similar to fresh, whole, human blood, the reference solution is stored in a sealed ampule under an inert atmosphere containing CO.sub.2 until just prior to use. The ampule is subsequently opened and the solution is equilibrated with a gas mixture having components which provide gasses in a physiological range to the solution. The solution is characterized by exhibiting properties similar to fresh blood subsequent to equilibration and an extended storage life prior to equilibration.

REFERENCES:
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International Search Report for PCT/US90/01422, filed Mar. 16, 1990, for Bionostics, Inc.
Sprokholt, R. and Maas, A. H. J., Physiology and Methodology of Blood Gases and pH, vol. 4: IFCC Workshop Oslo, 67-97 (1984).
Mansouri, A., Hemoglobin, 5(6): 579-589 (1981).
Masukawa, T. and Iwata H., Life Science, 21: 695-700 (1977).
Benesch, R. and Benesch, R., Nature, 221: 618-622 (1969).
Chanutin, A. and Curnish, R., Archives of Biochemistry and Biophysics, 121: 96-102 (1967).

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