Purified mammalian cell binding receptor for bacterial lipopolys

Details Purified mammalian cell binding receptor for bacterial lipopolys Purified mammalian cell binding receptor for bacterial lipopolys

1989-07-07

1991-09-03

Kepplinger, Esther L.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

530387, 530388, 435 7021, 4351722, 935104, 935108, 935 95, C12N 520, C07K 1528, C12P 2108

Patent

active

050454668

ABSTRACT:
The invention is directed to hydridoma cell lines and the monoclonal antibodies produced by the cell lines, where the monoclonal antibodies specifically bind to the lipopolysaccharide endotoxin binding receptor of mammalian cells. Specifically, the monoclonal antibodies binds to a cell receptor which has a molecular mass of 80 kilodaltons, and is specific for the lipid A component of the lipopolysaccharide endotoxin. The monoclonal antibodies are specific for a carbohydrate component of the binding receptor in one instance, and for a protein/peptide receptor in another.

REFERENCES:
Roeder et al., Infection and Immunity 57(4):1054-58, 1989.
Jakway et al., Fed. Proc. 44: 1297, 1985.
Wright et al., J. Exp. Med. 164: 1876-88, 1986.
Kipps & Herzenberg, pp. 108.1-108.9 in "Handbook of Expt'l Immunology", vol. 4, Herzenberg et al, Eds. 1986, Blackwell Sci. Publ.
Wright et al. J. Immunology, 144(7): 2566-71, 1990.

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