Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1988-06-29
1991-08-20
Rollins, John W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514888, 514915, A61K 3144
Patent
active
050414500
ABSTRACT:
The present invention contemplates a treatment for ocular inflammation.
More particularly, one aspect of the present invention relates to a method of reducing, inhibiting or preventing ocular inflammation in a mammal which comprises administering to said mammal an effective amount of matrine or a derivative thereof.
Another aspect of the present invention is directed to a pharmaceutical composition useful in reducing, inhibiting or preventing ocular inflammation in a mammal comprising an effective amount of matrine or a derivative thereof and a pharmaceutically acceptable carrier.
Yet another aspect of the present invention contemplates a method of inducing ocular analgesia and a pharmaceutical composition useful for same.
REFERENCES:
Polanksky et al. (1984) in Pharmacology of the Eye (Sears, M. L., ed) Springer-Valag, New York, pp. 459-538; Anti-Inflammatory Agents: Steroids as Anti-Inflammatory Agents.
Masuda (1984) in Pharmacology of the Eye (Sears, M. L., ed) Springer-Valag, New York, pp. 539-551; Anti-Inflammatory Agents: Nonsteroidal Anti-Inflammatory Drugs.
Cho et al. (1986) Planta Medica 5: 343-345; Study of the Antipyretic Activity of Matrine: A Lupin Alkaloid Isolated from Sophora subprostrata.
Cho et al. (1986) IRCS Med. Sci. 14, 441-442; Study of the Anti-Inflammatory Action of Matrine: An Alkaloid Isolated from Sophora subprostrata.
Chiou George C. Y.
Chuang Ching-Yao
Research Corporation Technologies Inc.
Rollins John W.
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