Oligonucleotides encloding peptide inhibitors of urokinase recep

Details Oligonucleotides encloding peptide inhibitors of urokinase recep Oligonucleotides encloding peptide inhibitors of urokinase recep

1995-05-10

1997-10-21

Walsh, Stephen

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 235, C12N 1511, C12N 1512

Patent

active

056797826

ABSTRACT:
Oligonucleotides encoding effective urokinase-type plasminogen activator receptor antagonists have amino acid sequences selected from the group AEPMPHSLNFSQYLWYT, AEWHPGLSFGSYLWSKT, AEHTYSSLWDTYSPLAF, AESSLWTRYAWPSMPSY, AELDLWMRHYPLSFSNR, AEWSFYNLHLPEPQTIF, AETLFMDLWHDKHILLT, AEPLDLWSLYSLPPLAM, AESLPTLTSILWGKESV, AESQTGTLNTLFWNTLR, AESSLWRIFSPSALMMS, AEPALLNWSFFFNPGLH, AEAWFLSNTMKALSARL, AEPTLWQLYQFPLRLSG, AEISFSELMWLRSTPAF, AEWITSSPPLTQYLWGF, AEMHRSLWEWYVPNQSA, AEIKTDEKMGLWDLYSM, AEILNFPLWHEPLWSTE, AELSEADLWITWFGMGS, AESVQYSKLWKPNTTLA, AEPLSLYQKKTLRHFAN, AELPRTNPVTAVKNPSF, AEQLNRSIPDLQFSMFN, and AESHIKSLLDSSTWFLP, or active analogs or active portions thereof.

REFERENCES:
patent: 5340833 (1994-08-01), Bridges
patent: 5416006 (1995-05-01), Blasi et al.
patent: 5519120 (1996-05-01), Dan.o slashed. et al.
Appella et al., J. Biol. Chem., "The Receptor-binding Sequences of Urokinase", (1987) 262(10):4437-4440.

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