Substituted benzoylguanidines, process for their preparation, th

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

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514520, 514521, 514522, 514622, 558415, 564162, 564163, 564169, 564142, A61K 31165, C07C23364

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active

056797125

ABSTRACT:
Benzoylguanidines of the formula I ##STR1## are described in which: R(1), R(2), R(3), R(4), R(5) are as defined in the specification, and pharmaceutically tolerated salts thereof.

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English language Derwent Abstract of DE-A-4318756, 1994.
"Inhibition of Na.sup.+ /H.sup.+ exchange suppresses nor-adrenaline release and arrhythmias in the ischemic rat heart", Schomig et al., Eur. Heart J., Book of Abstracts, 9(suppl. 1):167(1988).
"Amiloride: Antiarrhythmic and Electrophysiologic Actions in Patients With Inducible Sustained Ventricular Tachycardia", Duff et al., Circulation, 79(6):1257-1263(1989).

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