Liquid purification or separation – With means to add treating material – Chromatography
Patent
1991-06-17
1993-01-19
Therkorn, Ernest G.
Liquid purification or separation
With means to add treating material
Chromatography
210656, 210659, 210101, 210137, B01D 1508
Patent
active
051804875
ABSTRACT:
It is an object to provide a recycle chromatograph with supercritical fluid mobile phase for separating a sample into components by recycling a mobile phase which includes modifier solvent for the purpose of taking a desired component.
It is structured in such a manner that a recycling pump (10), a column (14), a detector (16), and a three-way valve (18) are connected in a sequential order as described above to form a closed loop which acts as a recycle flow line. A back-pressure regulator (20) is connected to the remainder port (C) of this three-way valve (18), and a mobile phase supplying and pressurizing device (30, 38, 30A, 48) for supplying the mobile phase under a predetermined pressure is connected to a flow line between the three-way valve (18) and the recycling pump (10).
By means of this mobile phase supplying and pressurizing device and the recycle closed loop, (the column pressure drop .DELTA.p)/(column plate number) can be reduced, whereupon the column effective plate number can be increased. Thus, a sufficient resolution rate for fractionating a component can be obtained after appropriate recycling times.
Furthermore, by combining the mobile phase supplying device (30, 38 30A, 38A, 48) and the back-pressure regulator (20), the internal pressures in the column and the detector can be kept above the critical pressure even if unnecessary components are being removed or a necessary component is being fractionated. As a result of which fractionation can be performed.
REFERENCES:
patent: 3398689 (1968-08-01), Allington
patent: 3443691 (1969-05-01), Nilsson
patent: 3686117 (1972-08-01), Lauer
patent: 4137161 (1979-01-01), Shimada
patent: 4239623 (1980-12-01), Schrenker
patent: 4271697 (1981-06-01), Mowery
patent: 4311586 (1982-01-01), Baldwin
patent: 4388184 (1983-06-01), Brow
patent: 4403866 (1983-09-01), Falcoff
patent: 4478720 (1984-10-01), Perrut
Snyder, Introduction to Modern Liquid Chromatography, John Wiley & Sons, Inc., New York pp. 519-522 & 98-99.
Saito Muneo
Yamauchi Yoshio
Nihon Bunko Kogyo Kabushiki Kaisha
Therkorn Ernest G.
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