Solvent for a sparingly soluble gentamicin salt

Details Solvent for a sparingly soluble gentamicin salt Solvent for a sparingly soluble gentamicin salt

1994-05-04

1997-10-21

Peselev, Elli

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 136, A61K 3170

Patent

active

056796463

ABSTRACT:
A solvent for the salt of gentamicin with 3-p-methoxybenzylidene-6-hydroxy-4 '-methoxyflavanone-6-phosphate which is a mixture of from 6 to 9.75 parts by volume of tetrahydrofuran and from 4 to 0.25 parts by volume of water. In these solvents the active compound is soluble up to about 60% by weight. Such a solution is particularly suitable for loading pharmaceutical carriers with this active compound.

REFERENCES:
patent: 4212860 (1980-07-01), Mc Combie
patent: 4843112 (1989-06-01), Gerhart et al.
patent: 4937257 (1990-06-01), Gericke et al.
The Merck Index, ninth edition (1976), p. 1187 No. 8929.
H. Wahlig et al., "Pharkokinetik und Gewebevertraglichkeit einer Tricalciumphosphate . . . ", Z Zahnarztl Implantol III, pp. 179-182 (1987) .

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