Cationic polymer and lipoprotein-containing system for gene deli

Details Cationic polymer and lipoprotein-containing system for gene deli Cationic polymer and lipoprotein-containing system for gene deli

1996-07-03

1997-10-21

Ketter, James

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

4284022, 530359, 536 231, C12N 1564, C12N 1588

Patent

active

056795599

ABSTRACT:
A composition for delivery of a selected nucleic acid into a targeted host cell comprises a complex of a hydrophobized, positively charged, biocompatible polymer; a lipoprotein; and a selected nucleic acid. Hydrophobic and electrostatic interactions between the components provide for the formation of the condensed DNA-containing complex. Preferred embodiments of the complex have a slightly positive surface charge and an average diameter of about 200 nm. Plasmids and oligonucleotides can be efficiently delivered with such compositions. A method of delivering a selected nucleic acid to a host cell is also disclosed.

REFERENCES:
patent: 5354844 (1994-10-01), Beug et al.

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