Production of recombinant factor VIII in the presence of liposom

Details Production of recombinant factor VIII in the presence of liposom Production of recombinant factor VIII in the presence of liposom

1995-05-04

1997-10-21

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4351723, 530383, C12P 2102

Patent

active

056795491

ABSTRACT:
Recombinant Factor VIII expression in a mammalian cell culture can be increased by including a novel liposome-like substance in the culture medium. The liposome-like substance comprises at least two (preferably at least three) different lipids in defined molar ratios. In a preferred embodiment, the addition of a liposome-like substance comprised of dioleoyl phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine in a molar ratio of 4:1:1 to the culture medium of GS-MDR cells resulted in an increase in FVIII production by a factor greater than five.

REFERENCES:
patent: 5198349 (1993-03-01), Kaufman

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