“Prionins”, highly specific markers for...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage

Reexamination Certificate

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C435S007100, C435S007940, C435S962000, C435S970000

Reexamination Certificate



Proteins expressed from within the prion protein genes of all animals and humans, “prionins”, against which reagents can be prepared for accurate pre-symptomatic diagnosis, for detecting latent TSE, for detecting TSE contamination of food, blood and blood products and for therapeutic treatment of Bovine spongiform encephalopathy (BSE) in cows, Scrapie disease in sheep and Creutzfeldt-Jacob syndrome in humans, are revealed.

patent: 125 023 (1984-04-01), None
patent: 171 496 (1985-03-01), None
patent: 173 494 (1985-08-01), None
patent: 184 187 (1985-12-01), None
patent: 86/01533 (1986-03-01), None
patent: 87/02671 (1987-05-01), None
Baranyi et al. (1995) “The antisense homology box: A new motif within proteins that encodes biologically active peptides”Nature Medicine1:894-901.
Beidler et al. (1988) “Cloning and high level expression of a chimeric antibody with specificity for human carcinoembryonic antigen”J. Immunol.141:4053-4060.
Bergmann et al. (1996) “‘Alzas’, a protein found in brain and blood of humans with Alzheimer's Disease (AD) but not in normal humans, appears to be the causative biochemical factor of all forms of AD”Neurobiology of Aging17:S14.
Better et al. (1988) “Escherichia coliSecretion of an Active Chimeric Antibody Fragment”Science240:1041-1043.
Blake et al. (1984) “A Rapid, Sensitive Method for Detection of Alkaline Phosphatase-Conjugated Anti-antibody on Western Blots”Anal. Biochem.136:175-179.
Bontems et al. (1991) “Refined Structure of Charybdotoxin: Common Motifs in Scorpion Toxins and Insect Defensins”Science254:1521-1523.
Collinge et al. (1996) “Molecular Analysis of Prion Strain Variation and the Aetiology of ‘New Variant’ CJD”Nature283:685-690.
Darcel (1995) “Reflections on Scrapie and Related Disorders, With Consideration of the Possibility of a Viral Aetiology”Vet. Res Commun.19:231-252.
Dluzewski et al. (1989) “Red Cell Membrane Protein Distribution During Malarial Invasion”,J. cell Sci.92:691-699.
Goldfarb et al. (1965) “The Transmissible Spongiform Encephalorathies”Annual Rev. Med.46:57-65.
Harrison (1996) “Peptide-surface Association: The case of PDZ and PTB Domains”Cell86:343-344.
Hill et al. (1991) “Crystal Structure of Defensin HNP-3, an Amphiphilic Dimer: Mechanisms of Membrane Permeabilization”Science251:1481-1485.
Hopp et al (1981) “Prediction of Protein Antigenic Determinants From Amino Acid Sequences”Proc. Natl. Acad. Sci. USA78:3824-3828.
Jones et al. (1986) “Replacing the Complementarity—Determining Regions in a Human Antibody With Those From a Mouse”Nature321:552-525.
Kaneko et al. (1998) Evidence for Protein X binding to a Discontinuous Epitope on the Cellular Prion Protein During Scrapie Prion PropagationProc. natl. Acad. Sci. USA94:10069-10074.
Kimberlin et al. (1989) “The Role of the Spleen in the Neuroinvasion of Scrapie in Mice”Virus Res.12:201-211.
Kozak (1984) “Compilation and Analysis of Sequences Upstream From the Translational Start Site in Eukaryotic mRNAs”Nucleic Acid Res.12:857-872.
Lasmezas et al. (1997) “Transmission of the BSE Agent to Mice in the Absence of Detectable Abnormal Prion Protein”Science275:402-405.
Liu et al. (1987) “Production of a Mouse-Human Chimeric Monoclonal Antibody to CD20 With Potent Fc-Dependent Biologic Activity”Proc. Natl. Acad. Sci. USA84:3439-3443.
Liu et al. (1987) “Chimeric Mouse-Human IgG1 Antibody That Can Mediate Lysis of Cancer Cells”J. Immunol.139:3521-3526.
Mestel (1996) “Putting Prions to the Test”Science273:184-189.
Morrison (1985) “Transfectomas Provide Novel Chimeric Antibodies”Science229:1202-1207.
Nishimura et al. (1987) “Recombinant Human-Mouse Chimeric Monoclonal Antibody Specific for Common Acute Lymphocytic Leukemia Antigen”Canc. Res.47:999-1005.
Oi et al. (1986) “Chimeric Antibodies”BioTechniques4:214.
Peitsch et al. (1990) “Localization and Molecular Modelling of the Membrane-Inserted Domain of the Ninth Component of Human Complement and Perforin”Mol. Immunol. 27 589-602.
Prusiner (1991) “Molecular Biology of Prion Diseases”Science252:1515-1522.
Prusiner (1996) “Transgenetics and Gene Targeting in Studies of Prion Diseases”Current topics in Microbiology and Immunology207:95-123.
Schägger et al. (1987) “Tricine-Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis for the Separation of Proteins in the Range From 1 to 100 kDa”Anal. Biochem.166:368-379.
Scheuner et al. (1996) “Secreted Amyloid β-protein Similar to That in the Senile Plaques of Alzheimer's Disease is Increased in vivo by the Presenilin 1 and 2 andAPPMutations Linked to Familial Alzheimer's Disease”Nature Medicine2:864-870.
Schmerling et al. (1998) “Expression of Amino-Terminally Truncated PrP in the Mouse Leading to Ataxia and Specific Cerebellar Lesions”Cell93:203-214.
Schreuder et al. (1996) “Preclinical Test for Prion Diseases”Nature381:563.
Shaw et al. (1988) “Mouse/Human Chimeric Antibodies to a Tumor-Associated Antigen: Biologic Activity of the Four Human IgG Subclasses”J. Natl. Cancer Inst.80:1553-1559.
Sun et al. (1987) “Chimeric Antibody with Human Constant Regions and Mouse Variable Regions Directed Against Carcinoma-Associated Antigen 17-1A”Proc. Natl. Acad. Sci. USA84:214-218.
Telling (1995) “Prion Propagation in Mice Expressing Human Chimeric PrP Transgenes Implicates the Interaction of Cellular PrP with Another Protein”Cell83:79-90.
van Leeuwen et al. (1998) “Frameshift Mutants of β Amyloid Precursor Protein and Ubiquitin-B in Alzheimer's and Down Patients”Science279:242-247.
Verhoeyan et al. (1988) “Reshaping Human Antibodies: Grafting an Antilysozyme Activity”Science239:1534.
Westaway et al. (1995) “On Safari with PrP: Prion Diseases of Animals”Trends. Microbiol.3:141-147.
Wills et al. (1989) “Induced Frameshifting Mechanism of Replication for an Information-Carrying Scrapie Prion”Microbiol. pathogenesis6:235-249.
Wood et al. (1985) “The Synthesis and in vivo Assembly of Functional Antibodies in Yeast”Nature214:446-449.
Yolken (1982) “Enzyme Immunoassays for the Detection of Infectious Antigens in Body Fluids: Current Limitations and Future Prospects”Rev. Infect. Dis.4:35.
Zhou et al. (1996) “Structural Basis for IL-4 Receptor Phosphopeptide Recognition by the IRS-1 PTB Domain”Nature Struct. Biol.3:388-393.


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