UCN-1028A and UCN-1028C and process for the production thereof

Organic compounds -- part of the class 532-570 series – Organic compounds – Cyclohexadiene having atoms double bonded directly at the 1-...

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435127, 435911, 435254, C07C 5010, C07C 5000, C12P 1500, C12N 114

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049925709

ABSTRACT:
UCN-1028A and UCN-1028C having an anti-tumor activity and a protein kinase C inhibitory activity are produced by culturing a microorganism belonging to the genus Cladosporium.

REFERENCES:
Laskin et al., "Handbook of Microbiology", vol. III, 1973, p. 255.
Nakano et al., "UCN-1028A . . . ", J. Antibiotics, 1989, 42(1), pp. 153-155.
Kobayashi et al., "Calphostin C (UCN-1028C) . . . ", Biochem. Biophys. Res. Commun., 1989, 159(2), pp. 548-553.
Arnone et al., "Secondary Mold Metabolites . . . ", Phytochemistry, 1988, 27(6), pp. 1675-1678.
Agricultural and Biological Chemistry 39, 1683 (1975), "Phleichrome, . . . ".

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