Macrocyclic chelating agent

Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...


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540452, 534 16, 534 15, A61K 3900, C07D25702




A novel bifunctional macrocyclic chelating agent useful for attaching metal ions to proteins, polypeptides and other polymers. These reagents are unique in their ability to bind a variety of metal ions and to yield a high metal ion concentration per protein molecule. Protein metal chelates thus obtained will have useful radiophysical, chemical, fluorescent, photochemical and magnetic properties suitable for biomedical applications.

patent: 4352751 (1982-10-01), Wieder et al.
patent: 4678667 (1987-07-01), Meares et al.
patent: 4885363 (1989-12-01), Tweedle et al.
patent: 5057302 (1991-10-01), Johnson et al.
patent: 5204448 (1993-04-01), Subramanian et al.
patent: 5342936 (1994-08-01), Parker et al.
patent: 5376357 (1994-12-01), Rajagopalan et al.
patent: 5428154 (1995-01-01), Gansow et al.
Subramanian et al., Cancer Imaging with Radiolabeled Antibodies, pp. 183-199 Kluwer Academic Publishers (1990).
D. A. O'Sullivan, C&EN, Aug. 16, 1993, p. 20.
Tomalia et al., Angew. Chem. Int. Ed. Engl., 29, 1990.
Moi et al., Inorganic Chemistry, 26:21:3458-3463, 1987.
Brechbiel et al., Inorganic Chemistry, 25:2772-2781, 1986.
Subramanian et al., Bioconjugate Chemistry, 3:3:248-255, 1992.
Lindmo et al., J. Immunol. Meth., 72:1:77-79, 1984.


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