C-20- And C-23-Modified macrolide derivatives

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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424180, C07H 1708

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active

044685114

ABSTRACT:
C-20- and C-23-Modified macrolide derivatives of demycinosyltylocin (DMT), 5-O-mycaminosyltylonolide (OMT) 23-de(mycinosyloxy)tylosin, 23-deoxy-OMT, 20-dihydro-20-deoxy-DMT and 20-dihydro-20-deoxy-OMT are useful antibiotics or intermediates to antibiotics.

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H. Matsubara et al., "Chemical Transformation of Tylosin, a 16-Membered Macrolide, and its Structure-Activity Relationship", Chem. Pharm. Bull., 30 (1), 97-110 (1982).
S. Omura et al., "Novel Dimeric Derivatives of Leucomycins and Tylosin, Sixteen-Membered Macrolides", J. Med. Chem. 25, 271-275 (1982).
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