C-20- And C-23-Modified macrolide derivatives

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives


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424180, C07H 1708




C-20- and C-23-Modified macrolide derivatives of demycinosyltylocin (DMT), 5-O-mycaminosyltylonolide (OMT) 23-de(mycinosyloxy)tylosin, 23-deoxy-OMT, 20-dihydro-20-deoxy-DMT and 20-dihydro-20-deoxy-OMT are useful antibiotics or intermediates to antibiotics.

patent: 3459853 (1969-08-01), Gorman et al.
patent: 4196280 (1980-04-01), Umezawa et al.
patent: 4279896 (1981-07-01), Ganguly et al.
patent: 4304856 (1981-12-01), Baltz et al.
patent: 4321361 (1982-03-01), Baltz et al.
patent: 4321362 (1982-03-01), Baltz et al.
patent: 4345069 (1982-08-01), Sakakibara et al.
H. Matsubara et al., "Chemical Transformation of Tylosin, a 16-Membered Macrolide, and its Structure-Activity Relationship", Chem. Pharm. Bull., 30 (1), 97-110 (1982).
S. Omura et al., "Novel Dimeric Derivatives of Leucomycins and Tylosin, Sixteen-Membered Macrolides", J. Med. Chem. 25, 271-275 (1982).
Derwent Abstract No. 71396Y of Japanese Unexamined Patent 2100-485 (Takeda), Aug. 23, 1977.
A. Tanaka et al., "Syntheses of 4'-Deoxy-Demycarosyl Tylosin and its Analogues", J. Antibiotics 34 (10), 1381-1384 (1981).
S. Satoi et al., "Mycinamicins, New Macrolide Antibiotics, I: Taxonomy, Production, Isolation, Characterization and Properties", J. Antibiotics 33 (4), 364-377 (1980).
A. Tanaka et al., "Syntheses of 23-Dialkylamino Derivatives of Mycaminosyl Tylonolide and 4'-Deoxymycaminosyl Tylonolide Effective Against Gram-Negative Bacteria", J. Antibiotics 35 (1), 113-116 (1982).
A. Tanaka et al., "Synthesis of 4'-Deoxymycaminosyl Tylonolide", J. Antibiotics 34 (10), 1374-1376 (1981).
A. Tanaka et al., "Synthesis of Derivatives of 4'-Deoxymycaminosyl Tylonolide and Mycaminosyl Tylonolide Modified at C-23", J. Antibiotics 34 (10), 1377-1380 (1981).
Derwent Abstract No. 92092A/51 of Japanese Unexamined Patent 3130-686 (Toyo Brewing), Nov. 14, 1978.
Derwent Abstract No. 008688/01 of Japanese Unexamined Patent 3132-584 (Toyo Brewing), Nov. 18, 1978.
Derwent Abstract No. 65537B/36 of Japanese Unexamined Patent 4095-584 (Toyo Brewing), Jul. 28, 1979.


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