Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1984-02-13
1984-11-06
Roberts, Elbert L.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
2603972, A61K 5139, C07J 900
Patent
active
044811985
ABSTRACT:
This invention provides a novel vitamin D derivative, namely a 24-oxime derivative of vitamin D.sub.3, and a process for its preparation. The compound of this invention is an effective inhibitor of vitamin D-25-hydroxylation and markedly suppresses the formation of the physiologically active vitamin D metabolites. The compound would thus find use as an effective antagonist of vitamin D activation, and for treating hypercalcemic conditions resulting from metabolic, bone, or neoplastic diseases, or from vitamin D intoxication.
REFERENCES:
patent: 4199577 (1980-04-01), Takeshita et al.
Hey et al., J. Chem. Soc. 2881 (1950).
Chu John Y.
DeLuca Hector F.
Kabakoff Bruce D.
Schnoes Heinrich K.
Bremer Howard W.
Roberts Elbert L.
Wisconsin Alumni Research Foundation
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