Vaccine for branhamella catarrhalis

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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4353201, 4352521, 435 871, 435 911, 435 914T, 4352351, 4351723, 536 221, 536 231, 530350, C12N 1500, C12N 700, C07K 100, C07H 1900

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057121184

ABSTRACT:
Compositions comprising outer membrane protein "CD", and peptides and oligopeptides thereof, of Branhamella catarrhalis are described. Additionally, nucleotide sequences encoding the protein, peptide or oligopeptide are disclosed, as well as recombinant vectors containing these sequences. Protein, peptide or oligopeptide can be produced from host cell systems containing these recombinant vectors. Peptides and oligopeptides can also be chemically synthesized. Disclosed are the uses of the protein, peptides and oligopeptides as antigens for vaccine formulations, and as antigens in diagnostic immunoassays. The nucleotide sequences are useful for constructing vectors for use as vaccines for insertion into attenuated bacteria in constructing a recombinant bacterial vaccine, and for inserting into a viral vector in constructing a recombinant viral vaccine. Also described is the use of nucleotide sequences related to the gene encoding CD as primers and/or probes in molecular diagnostic assays for the detection of B. catarrhalis.

REFERENCES:
patent: 5556755 (1996-09-01), Murphy
Murphy et al. 1993. The major heat-modifiable outer membrane protein CD . . . Mal. Microbiol. 10(1):87-97.
Helminen et al. 1993. A major outer membrane protein of Moraxella catahrhalis . . . 61(5):2003-2010.
Houghten et al. 1986. Vaccines 86. pp. 21-25.
Sarwar et al. 1992. Inf & Irnm. 60(3):804-809.

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