Drug – bio-affecting and body treating compositions – Lymphokine
Patent
1984-08-21
1988-09-06
Hazel, Blondel
Drug, bio-affecting and body treating compositions
Lymphokine
514 12, 435 68, 435320, 536 27, A61K 3912, A61K 3925, C12P 2100, C12N 1500
Patent
active
047692391
ABSTRACT:
A gene of varicella-zoster virus (VZV) which encodes immunogenic outer surface viral proteins has been identified through DNA sequence analysis. Fragments of the DNA have been cloned into a vector which, when placed into a host organism, expresses proteins which react with human convalescent zoster sera and with monoclonal antibodies which neutralize viral infectivity. These proteins are useful for preparation of a vaccine for VZV.
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Ellis Ronald W.
Keller Paul M.
Hazel Blondel
Merck & Co. , Inc.
Perrella Donald J.
Pfeiffer Hesna J.
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