Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1985-04-22
1988-04-26
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514326, 514330, 514422, 514423, 544300, 546206, 546227, 546238, 546256, 548523, 548527, 548530, 548532, 548535, 564153, 564168, 564185, C07D40100, C07D21106, C07D21160, A61K 3144
Patent
active
047405082
ABSTRACT:
Compounds of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.
REFERENCES:
patent: 4329473 (1982-05-01), Almquist et al.
patent: 4621092 (1986-11-01), Natarajan et al.
patent: 4623729 (1986-11-01), Natarajan et al.
Meyer et al., "Novel Synthesis of . . . ", J. Med. Chem., 1981, vol. 24, pp. 964-969.
Almquist et al., "Derivatives of Potent Angiotensin Converting Enzyme Inhibitor . . . ", J. Med. Chem., 1982, vol. 25, 1292-1299.
Gordon Eric M.
Weller, III Harold N.
Covington Raymond
Davis Stephen B.
E. R. Squibb & Sons Inc.
Levinson Lawrence S.
Raymond Richard L.
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