Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-09-25
1990-12-04
Ford, John M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549 20, 549458, 549462, A61K 3134, C07D30780
Patent
active
049754572
ABSTRACT:
Certain trans-2,3-disubstituted-2,3-dihydro-5-hydroxybenzofurans are described. The synthesis involves an intramolecular Michael addition to yield the thermodynamic trans isomer. The compounds were found to be inhibitors of 5-lipoxygenase, an enzyme crucial to the biosynthesis of leukotrienes and useful for the treatment of various inflammatory diseases.
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K. Brannock, et al., J. Org. Chem., 29, 2579, (1964).
Boger Joshua S.
Rupprecht Kathleen M.
Dentz Bernard I.
Ford John M.
Merck & Co. , Inc.
Nicholson William H.
Panzer Curtis C.
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