Topically active compositions of mismatched dsRNAs

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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536 231, 128844, 514934, A61K 31715, A61K 604, C07H 2102

Patent

active

057122571

ABSTRACT:
Surfactant-stabilized ternary complexes of dsRNAs in topical pharmaceutical compositions, optionally also including a lymphokine and/or an inhibitor of reverse transcriptase, are applied topically to the affected or exposed area to treat or prevent viral infections, such as herpes virus, and other infectious conditions, particularly venereally transmitted pathogens. Ternary complexes of two strands of complementary RNA plus a compatible surfactant stabilized against temperature-associated enzymatic inactivation are described.

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Hicks et al, The Lancet, vol. II No. 8469/70, pp. 1422, 1423, Dec. 21/28, 1985.
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Journal of Biological Response Modifiers 4:495-502, 1985, Raven Press "Preclinical Studies with Ampligen (Mismatched Double Stranded RNA)", Carter et al.

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