Synthetic peptide inhibitors of HIV transmission

Details Synthetic peptide inhibitors of HIV transmission Synthetic peptide inhibitors of HIV transmission

1995-11-06

2000-10-17

Stucker, Jeffrey

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

530333, 435974, A61K 3800

Patent

active

061334189

ABSTRACT:
The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention comprise DP-178 (SEQ ID:1) ptide corresponding to amino acids 638 to 673 of the HIV-1.sub.LAI gp41 protein, and fragments, analogs and homologs of DP-178. The invention further relates to the uses of such peptides as inhibitory of human and non-human retroviral, especially HIV, transmission to uninfected cells.

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