Synthesis of tumor antigenic determinant

Details Synthesis of tumor antigenic determinant Synthesis of tumor antigenic determinant

1987-08-17

1988-08-30

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

538 53, C07H 1500, C07H 1506

Patent

active

047678453

ABSTRACT:
Processes are provided for the synthesis of the human T-antigenic determinant 2-acetamido-2-deoxy-3-O-(.beta.-D-galactopyranosyl)-.alpha.-D-galactopyran oside containing an .alpha.-O-glycosidically linked bridging arm O--(CH.sub.2).sub.n COR. The determinant is coupled to carrier molecules to form artificial T-antigens, and to insoluble supports to form T-immunoadsorbents. The artifical T-antigen is shown to elicit a delayed type hypersensitivity reaction as a diagnostic for the presence of cancer in humans.

REFERENCES:
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patent: 4195174 (1980-03-01), Lemieux et al.
Kaifu and Osawa, Carbohydrate Res., 58:235-39 (1977), Elsevier Scientific Publishing Co., Amsterdam, Netherlands.
Kaifu and Osawa, Carbohydrate Res., 69:79-88 (1979), Elsevier Scientific Publishing Co., Amsterdam, Netherlands.
Bochkov and Zaikov, Chemistry of the O-Glycosidic Bond, 51-78 (1979).
Lemieux and Ratcliffe, Can. J. Chem., 57:1244 (1979).
Paulsen, Angewandte Chemie, Intl. Ed., 21:155 (1982).
Hoppner et al., Vox Sang., 48:246 (1985).
Hoppner et al., Molecul. Immunol., 22:1341 (1985).
Ratcliffe et al., Carbohydrate Research, vol. 93, pp. 35-41, Elsevier Scientific Publishing Co., Amsterdam, Netherlands (1981).

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