Substituted 2-aminotetralins useful as dopaminergics

Details Substituted 2-aminotetralins useful as dopaminergics Substituted 2-aminotetralins useful as dopaminergics

1991-09-11

1992-06-02

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514351, 514357, 514417, 514424, 514425, 514427, 514443, 514471, 514472, 548472, 548477, 548482, 548546, 548550, 548561, 548562, 548564, 546330, 546333, 546334, 546335, 549 55, 549 68, 549480, 549491, A61K 3140, C07D20944, C07D20948

Patent

active

051187043

ABSTRACT:
Optically active or racemic compounds are provided having the formula ##STR1## where R.sub.2, R.sub.3, R.sub.4 and R.sub.6 are defined in the specification; R.sub.1 is selected from the group consisting of ##STR2## wherein Y is selected from the group consisting of hydroxy, nitro, cyano, azido, amino, acylamino, carboxyamido, trifluoromethyl, sulfate, sulfonamido, halogen, hydrocarbyl and hetero atom-substituted hydrocarbyl radicals, wherein said heteroatoms are selected from the group consisting of halogen, nitrogen, oxygen, sulfur and phosphorus and said hydrocarbyl radicals comprise from 1 to 12, preferably 1 to 6, carbon atoms, and a is an integer of from zero to 3, for instance zero to 2; and pharmaceutically acceptable salts thereof; as dopaminergics.

REFERENCES:
Gleanon et al "Derivatives of Serotonergic Agents" J. Med. Chem 32 1921-1926 (1989).
Cecil "Medical Textbook" p. 1942, 1983.

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