Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Patent
1985-12-23
1986-11-25
Killos, Paul J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
562463, 562464, C07C 6976
Patent
active
046250476
ABSTRACT:
The invention relates to novel substituted [2,3-dihydro-4-(3-oxo-1-cyclohexen-1-yl)phenoxy]-alkanoic acids their derivatives and their salts. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke (particularly ischemic), arrested breathing, cardiac arrest, Reye's syndrome, cerebral thrombosis, cerebral embolism, cerebral hemorrhage, cerebral tumors, encephalomyelitis, spinal cord injury, hydrocephalus, post-operative brain injury trauma, edema due to cerebral infections and various brain concussions.
REFERENCES:
patent: 4337354 (1982-06-01), Cragoe, Jr. et al.
patent: 4356313 (1982-10-01), Cragoe et al.
patent: 4585888 (1986-04-01), Urban
"Agents for the Treatment of Brain Injury" 1. (Aryloxy) Alkanoic Acids, Cragoe et al., J. Med. Chem. (1982), 25 567-579.
Cragoe, Jr. Edward J.
Pietruszkiewicz Adolph M.
Woltersdorf, Jr. Otto W.
Caruso Charles M.
Killos Paul J.
Merck & Co. , Inc.
Pfeiffer Hesna J.
Szura Daniel T.
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