Substituted 2-(2,6 dioxo-3-fluoropiperidin-3-yl)-isoindolines an

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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546201, A61K 31445, C07D40104

Patent

active

058744487

ABSTRACT:
1-Oxo-2-(2,6-dioxo-3-fluoropiperidin-3-yl)isoindolines and 1,3-dioxo-2-(2,6-dioxo-3-fluoropiperidin-3-yl)isoindolines reduce the levels of TNF.alpha. in a mammal. A typical embodiment is 1,3-dioxo-2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindoline.

REFERENCES:
patent: 5385901 (1995-01-01), Kaplan
patent: 5635517 (1997-06-01), Muller
patent: 5798368 (1998-08-01), Muller

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