Substituted 1,5-naphthyridine azolinones

Details Substituted 1,5-naphthyridine azolinones Substituted 1,5-naphthyridine azolinones

2007-12-04

2007-12-04

Seaman, Margaret D. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S122000

Reexamination Certificate

active

11368936

ABSTRACT:
Substituted 1,5-naphthyridine azolinones inhibit Cdk1 and are selective against Cdk2 and Cdk4. These compounds and their pharmaceutically acceptable salts have antiproliferative activity and are useful as anti-cancer agents.

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